Zolin V V, Agafonova O A, Kolokol'tsov A A, Danilenko E D, Fedosova L K, Gamaleĭ S G, Omigov V V, Fadina V A, Masycheva V I
Vestn Ross Akad Med Nauk. 2001(5):27-31.
Human liposomal recombinant alpha 2b-interferon topically applied to laboratory animals was tested for antiviral activity, pharmacokinetics, and toxicity. The interferon was shown to penetrate through the skin and to circulate in the blood of experimental animals longer than its injectable form, and to exhibit its antiviral activity against genital herpes in guinea pigs. It produced no toxic, skin-irritant, or allergic effects in laboratory animals.
将人脂质体重组α2b干扰素局部应用于实验动物，对其抗病毒活性、药代动力学和毒性进行了测试。结果表明，该干扰素能够穿透皮肤，在实验动物血液中的循环时间比其注射剂型更长，并且对豚鼠的生殖器疱疹具有抗病毒活性。它在实验动物中未产生毒性、皮肤刺激性或过敏反应。
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