Pathophysiology of osteoporosis and fracture.

Bone is a vital, dynamic tissue that performs many functions, including a major role in serum homeostasis. A complex interplay of factors affects bone function and bone health. This article provides an overview of bone physiology and the pathophysiology of osteoporosis and fragility fracture. An understanding of the material presented here will provide a foundation to assess the bone health of individuals, to promote bone health, and to prevent fracture in patients of all ages.