Vallinoto Antonio C.R., Cayres-Vallinoto Izaura M.V., Ribeiro Dos Santos ÂK Ândrea K.C., Zago Marco A., Santos Sidney E.B., Guerreiro João F.
Laboratory of Human and Medical Genetics, Federal University of Pará, 66075-900 Belém, Pará, Brazil.
Am J Hum Biol. 1999;11(4):481-487. doi: 10.1002/(SICI)1520-6300(1999)11:4<481::AID-AJHB7>3.0.CO;2-2.
The allele frequency distribution of DYS19 and DYS199 loci were analyzed in 59 Brazilian Amerindians from five tribes from the Amazon region (Zoé, Awá-Guajá, Urubú-Kaapór, Katuena, and Kayapó, Xikrin of Bacajá village). Three different alleles of the DYS19 microsatellite (182-bp, 186-bp, and 190-bp) were found at average frequencies of 0.08, 0.85, and 0.07, respectively. The DYS199-T allele was identified in 78% of the Amerindians studied (43/55), the frequencies varying from 0.46-0.93. Four different haplotypes were found, the combination DYS19-186/DYS199-T being the most common (average frequency of 0.65), followed by DYS19-186/DYS199-C with an average frequency of 0.22. These four haplotypes have been found in five other Brazilian tribes, and most of them were also identified in Native populations from South, Central and North America. The observed variability at the DYS19 microsatellite is probably due to forward or back mutations from the putative ancestral 186-bp allele, since the mutation rate of this locus is high and the post-Columbian admixture of the Brazilian tribes studied is very low or undetectable to explain these data. On the other hand, the DYS19/DYS199 haplotype distribution may suggest that the two most common haplotypes (186-bp/T and 186-bp/C) were present among the population(s) that peopled the New World. Am. J. Hum. Biol. 11:481-487, 1999. Copyright 1999 Wiley-Liss, Inc.
对来自亚马逊地区五个部落（佐埃、阿瓦-瓜贾、乌鲁布-卡波尔、卡图埃纳和巴卡亚村的西克林族凯亚波）的59名巴西印第安人的DYS19和DYS199基因座的等位基因频率分布进行了分析。发现DYS19微卫星的三种不同等位基因（182 bp、186 bp和190 bp），其平均频率分别为0.08、0.85和0.07。在所研究的78%的印第安人（43/55）中鉴定出DYS199 - T等位基因，频率在0.46 - 0.93之间变化。发现了四种不同的单倍型，DYS19 - 186/DYS199 - T组合最为常见（平均频率为0.65），其次是DYS19 - 186/DYS199 - C，平均频率为0.22。这四种单倍型在其他五个巴西部落中也有发现，并且其中大多数也在南美洲、中美洲和北美洲的原住民群体中被鉴定出来。DYS19微卫星处观察到的变异性可能是由于假定的祖先186 bp等位基因发生正向或反向突变所致，因为该基因座的突变率很高，且所研究的巴西部落的后哥伦布时期混合程度非常低或无法检测到，无法解释这些数据。另一方面，DYS19/DYS199单倍型分布可能表明，两种最常见的单倍型（186 bp/T和186 bp/C）在最初定居新世界的人群中就已存在。《美国人类生物学杂志》11:481 - 487，1999年。版权所有1999威利 - 利斯公司。
