Dwinell K L, Bass P, Telford G L, Oaks J A
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA.
J Parasitol. 2001 Aug;87(4):721-4. doi: 10.1645/0022-3395(2001)087[0721:EOSAOT]2.0.CO;2.
Eight groups of rats were used to study the involvement of the enteric (ENS) and central (CNS) nervous systems in the development of Hymenolepis diminuta using surgical intestinal transection, or CNS denervation, or both procedures. The transection procedure was used to isolate the ENS of the small intestine from either orad and/or caudal portions of the alimentary system, while the CNS denervation was used to eliminate direct visceral efferent inputs from the CNS. Nine days after the surgical procedures, all rats were infected with 35 cysticercoids of H. diminuta. On 20 days postinfection, the infection intensity, tapeworm dry weight, tapeworm morphology, intestine length, and intestinal wet weight were recorded. Only the combination of the duodenal and ileal transections with a CNS denervation reduced infection intensity and prevented the increased intestinal length normally observed in infected rats. In contrast, none of the various intestinal transection procedures alone or CNS denervation alone had any effect on the survival, ability to produce oncospheres or morphology of the tapeworms. In conclusion, tapeworm survival is decreased when both CNS and ENS inputs into the small intestine are altered or absent.
八组大鼠被用于研究肠道神经系统（ENS）和中枢神经系统（CNS）在微小膜壳绦虫发育过程中的作用，采用手术切断肠道、或去神经支配中枢神经系统、或两种方法并用。切断手术用于将小肠的肠道神经系统与消化系统的头端和/或尾端部分隔离开来，而去神经支配中枢神经系统则用于消除来自中枢神经系统的直接内脏传出输入。手术操作九天后，所有大鼠均感染35个微小膜壳绦虫的囊尾蚴。感染后20天，记录感染强度、绦虫干重、绦虫形态、肠长度和肠湿重。只有十二指肠和回肠切断术与去神经支配中枢神经系统相结合的方法降低了感染强度，并防止了感染大鼠中通常观察到的肠长度增加。相反，单独的各种肠道切断手术或单独的去神经支配中枢神经系统，对绦虫的存活、产生六钩蚴的能力或形态均无任何影响。总之，当进入小肠的中枢神经系统和肠道神经系统输入均改变或缺失时，绦虫的存活率会降低。
