白细胞跨内皮迁移：调控潜在分子机制
Leukocyte transendothelial migration: orchestrating the underlying molecular machinery.
作者信息
Worthylake R A, Burridge K
机构信息
Department of Cell and Developmental Biology, CB #7090, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
出版信息
Curr Opin Cell Biol. 2001 Oct;13(5):569-77. doi: 10.1016/s0955-0674(00)00253-2.
Transendothelial migration of leukocytes involves the spatiotemporal regulation of adhesion molecules, chemokines and cytoskeletal regulators. Recent results show that distinct steps of leukocyte transendothelial migration are regulated by sequential integrin activation and coordinated Rho family GTPase activity. Progress has been made in understanding how the dynamic regulation of these molecules translates into leukocyte transmigration.
白细胞的跨内皮迁移涉及黏附分子、趋化因子和细胞骨架调节因子的时空调控。最近的研究结果表明，白细胞跨内皮迁移的不同步骤受到整合素的顺序激活和Rho家族GTP酶活性协同作用的调控。在理解这些分子的动态调控如何转化为白细胞跨内皮迁移方面已取得进展。
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