血液透析期间，体内白细胞上的CD31表达下调。

CD31 expression on leukocytes is downregulated in vivo during hemodialysis.

作者信息

Kawabata K, Nakai S, Miwa M, Sugiura T, Otsuka Y, Shinzato T, Hiki N, Tomimatsu I, Ushida Y, Hosono F, Maeda K

机构信息

Department of Internal Medicine, Daiko Medical Center, Nagoya University School of Medicine, Nagoya, Japan.

出版信息

Nephron. 2001 Oct;89(2):153-60. doi: 10.1159/000046062.

DOI:10.1159/000046062

PMID:11549897

Abstract

BACKGROUND/AIM: CD31 on leukocytes is the adhesion molecule involved in the leukocyte extravasation in inflammatory conditions. During hemodialysis with cellulosic membranes, it is considered that activated leukocytes adhere to endothelium, but do not show extravasation. However, it is not elucidated why activated leukocytes do not show endothelial transmigration during hemodialysis with cellulosic membranes.

METHODS

In the present study, changes in the expressions of Mac-1 and CD31 on granulocytes and monocytes were analyzed by flow cytometry during hemodialysis in 7 patients treated with regenerated-cellulose (RC) membranes and next with polysulfone (PS) membranes.

RESULTS

During dialysis with RC, Mac-1 expressions on granulocytes and monocytes both significantly increased as compared with predialysis values and across the dialyzer. During dialysis with RC, the CD31 expression on granulocytes and monocytes significantly decreased as compared with predialysis values. During dialysis with PS, changes in Mac-1 and CD31 expressions on granulocytes and monocytes were smaller than those during dialysis with RC.

CONCLUSIONS

Decreased CD31 expression on leukocytes may affect leukocyte function more in patients chronically hemodialyzed with RC than in those hemodialyzed with PS, since CD31 is important in leukocyte transendothelial migration in inflammatory conditions.

摘要

背景/目的：白细胞上的CD31是炎症状态下参与白细胞外渗的黏附分子。在用纤维素膜进行血液透析期间，人们认为活化的白细胞会黏附于内皮，但不会发生外渗。然而，在用纤维素膜进行血液透析期间活化的白细胞为何不发生内皮迁移尚未阐明。