肠吸附剂诺利石对小鼠大脑行为和5-羟色胺（1A）受体的影响。
Effect of enterosorbent noolith on behavior and serotonin (1A) receptors in mouse brain.
作者信息
Borodin Y I, Avgustinovich D F, Tenditnik M V, Rachkovskaya L N, Shurlygina A V, Trufakin V A
机构信息
Laboratory of Immunomorphology, Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Science.
出版信息
Bull Exp Biol Med. 2001 May;131(5):496-8. doi: 10.1023/a:1017900704638.
Protective properties of a new enterosorbent noolith (lithium ions immobilized on mineral matrix) were studied in C57Bl/6J mice predisposed to depression caused by intermale confrontations. The drug was administered daily for 15 days after the 5th confrontation and then the animals were tested in the forced swimming test. The number of specific(3)H-8-OH-DPAT binding sites in 3 brain regions was determined. It is shown that noolith produced an antidepressive effect manifested in decreased immobility time in the Porsolt test. Moreover, noolith reduced the number of 1A-serotonin receptors in the frontal cortex and hypothalamus. It is concluded that noolith possesses protective properties.
在易因雄性间对抗而患抑郁症的C57Bl/6J小鼠中研究了一种新型肠吸附剂诺利石（固定在矿物基质上的锂离子）的保护特性。在第5次对抗后每天给药15天，然后在强迫游泳试验中对动物进行测试。测定了3个脑区中特异性（3）H-8-OH-DPAT结合位点的数量。结果表明，诺利石产生了抗抑郁作用，表现为在波索尔特试验中不动时间减少。此外，诺利石减少了额叶皮质和下丘脑1A-血清素受体的数量。得出结论，诺利石具有保护特性。
Zotero 插件