Histopathological study of six cases of Castleman's tumor.

A histopathological analysis of six cases of Castleman's tumor by means of light and electron microscope was performed, with a review of literature. All cases were hyaline-vascular type as described by Keller et al. The morphology of lymphnoid follicles in the lesions varied according to the presence or non-presence of the germinal center which was from large active to amaciated hyalinized. The lymphnoid follicle was essentially similar to that of normal lymph node undergoing some reactive process. Depending on the observation of serial sections, the lesions had lymphatic sinuses around the blood vessels in the tumor parenchyma, some of which were proved to be connected to the abortive marginal sinuses. These findings and some clinical records suggest that the lesion originates from the lymph node and is a result of its reactive hyperplasia.