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[一组进行性核上性麻痹患者的描述性研究]

[Descriptive study of a serie of patients affected by progressive supranuclear palsy].

作者信息

Villanueva-Haba V E, Garcés M, de Vera A, Valero C, Burguera J A

机构信息

Servicio de Neurología; Hospital Universitario La Fe, Valencia, 46009, España.

出版信息

Rev Neurol. 2001;32(11):1027-30.

Abstract

INTRODUCTION

Progressive supranuclear palsy is a neurodegenerative disorder affecting diverse neurologic systems. The actual treatment response is poor in most patients.

OBJECTIVE

review of a long series of patients affected by PSP in several aspects.

PATIENTS AND METHODS

A series of patients was reviewed by means of the register questionnaire of PSP in Spain (from PSP Disabling Rating Scale and Staging System). This is carried out on the patients when the diagnostic is done. It was achieved a descriptive of the patients, in several aspects, and an evaluation of the treatment in relation to the dose and the duration.

RESULTS

In general, the age of diagnostic is 66 years, there is not neurological illness in the family, falls and disorders of gait are the most representative parameters. The neuroimage shows fronto temporal atrophy. The treatment response is poor, despite the dose and the duration.

CONCLUSIONS

Our series confirms the typical dates of the illness an the poor response to treatment with L Dopa.

摘要

引言

进行性核上性麻痹是一种影响多种神经系统的神经退行性疾病。大多数患者的实际治疗反应较差。

目的

从多个方面回顾一系列受进行性核上性麻痹影响的患者。

患者与方法

通过西班牙进行性核上性麻痹登记问卷(来自进行性核上性麻痹致残评定量表和分期系统)对一系列患者进行回顾。这在诊断时对患者进行。实现了对患者多个方面的描述以及对与剂量和持续时间相关的治疗的评估。

结果

总体而言,诊断年龄为66岁,家族中无神经疾病,跌倒和步态障碍是最具代表性的参数。神经影像显示额颞叶萎缩。尽管有剂量和持续时间,但治疗反应较差。

结论

我们的系列研究证实了该疾病的典型数据以及左旋多巴治疗反应较差。

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