针对HIV-1 TSAO耐药菌株的“第二代”TSAO化合物。

"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains.

作者信息

Lobatón E, Velázquez S, Pérez-Pérez M J, Jimeno M L, San-Félix A, De Clercq E, Balzarini J, Camarasa M J

机构信息

Instituto de Química Médica (C.S.I.C.), Madrid, Spain.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):707-10. doi: 10.1081/NCN-100002356.

DOI:10.1081/NCN-100002356

Abstract

A "second generation" of TSAO molecules directed against TSAO-resistant strains have been prepared. The presence of two neighboring carbonyl groups at the 4" position of the 3'-spiro moiety seems to be important for the anti-HIV-1 activity against both wild type and TSAO-resistant strains. NMR conformational studies in solution and theoretical calculations of the novel compounds have also been carried out.

摘要

已经制备了针对对TSAO耐药菌株的“第二代”TSAO分子。3'-螺环部分4''位置上两个相邻羰基的存在对于抗野生型和TSAO耐药菌株的抗HIV-1活性似乎很重要。还对新型化合物进行了溶液中的NMR构象研究和理论计算。

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