Sardana M K, Satyanarayana Rao M R, Padmanaban G
Biochem J. 1975 Apr;147(1):185-6. doi: 10.1042/bj1470185.
The porphyrogenic drug allylisopropylacetamide, a potent inducer of delta-aminolaevulinate synthetase, specifically increases nucleoplasmic RNA synthesis in rat liver. The drug-mediated increase in nucleoplasmic RNA synthesis is blocked by cycloheximide and haemin, which also inhibit the enzyme induction.
致卟啉药物烯丙基异丙基乙酰胺是δ-氨基-γ-酮戊酸合成酶的强效诱导剂,可特异性增加大鼠肝脏核质RNA的合成。环己酰亚胺和血红素可阻断药物介导的核质RNA合成增加,它们也抑制该酶的诱导。