一种人类滑膜细胞抗原的特性：血管细胞黏附分子-1与炎性关节炎
Characterization of a human synovial cell antigen: VCAM-1 and inflammatory arthritis.
作者信息
Carter R A, O'Donnell K, Sachthep S, Cicuttini F, Boyd A W, Wicks I P
机构信息
Reid Rheumatology Laboratory, Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
出版信息
Immunol Cell Biol. 2001 Oct;79(5):419-28. doi: 10.1046/j.1440-1711.2001.01019.x.
The contribution of synovial cells to the pathogenesis of rheumatoid arthritis (RA) is only partly understood. Monoclonal antibody (mAb) 1D5 is one of very few mAb ever raised against RA synovial cells in order to study the biology of these cells. Studies on the expression pattern and structural features of the 1D5 Ag suggest that 1D5 recognizes human vascular cell adhesion molecule-1 (VCAM-1), which is an intercellular adhesion molecule. Vascular cell adhesion molecule-1 may be involved in a number of crucial intercellular interactions in RA.
滑膜细胞在类风湿性关节炎（RA）发病机制中的作用仅得到部分理解。单克隆抗体（mAb）1D5是为研究这些细胞生物学特性而制备的极少数针对RA滑膜细胞的单克隆抗体之一。对1D5抗原表达模式和结构特征的研究表明，1D5识别的是人类血管细胞黏附分子-1（VCAM-1），它是一种细胞间黏附分子。血管细胞黏附分子-1可能参与了RA中许多关键的细胞间相互作用。
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