Redl G, Trauner S, Cumlivski R, Fuchs R
Orthopädisches Spital Speising, Abteilung Anästhesie, Wien, Germany.
Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 Aug;36(8):465-70. doi: 10.1055/s-2001-16670.
We tested the hypothesis that blood saving techniques are more effective in patients with a low baseline haemoglobin.
We analysed retrospectively 1665 total hip replacements and 848 total knee replacements. Patients were divided in three groups according to the baseline haemoglobin (Hb): Group A were patients with a Hb of more than 15 g/dl, group B between 15 g/dl and 13 g/dl and group C with a Hb of less than 13 g/dl. The blood saving techniques applied (Preoperative blood donation, isovolemic haemodilution, and mechanical autotransfusion) aimed to a high patient population which underwent surgery without transfusion of homologous blood.
The higher the baseline value of haemoglobin the higher was the patient population without homologous blood transfusion. The lower the Hb the higher was the effectiveness of blood saving techniques. In case of total hip replacement preoperative blood donation increased the patient population without homologous blood transfusion in all three groups significantly. However, in case of total knee replacement preoperative blood donation increased the patient population without homologous blood transfusion only in group B and C significantly. In both surgical procedures the combination of preoperative blood donation with other blood saving techniques did not further increase the patient population without homologous blood transfusion. In total hip replacement mechanical autotransfusion as well as isovolemic haemodilution reduced homologous transfusion in patients with low baseline haemoglobin. However, the increase was more pronounced when both techniques were combined.
From our data is derived that the likelihood of homologous blood transfusion is greater in patients with a low baseline haemoglobin. However, in case of hip arthroplasty patients with a high baseline haemoglobin also profit from blood saving techniques while in case of knee arthroplasty the efficiency of blood saving techniques in a patient population with a high baseline haemoglobin is negligible. It seems to make sense to evaluate for the different kinds of surgery those patients who profit most from the different blood saving techniques.
我们检验了这样一个假设,即血液保存技术在基线血红蛋白水平较低的患者中更有效。
我们回顾性分析了1665例全髋关节置换术和848例全膝关节置换术。根据基线血红蛋白(Hb)将患者分为三组:A组为Hb超过15 g/dl的患者,B组为Hb在15 g/dl至13 g/dl之间的患者,C组为Hb低于13 g/dl的患者。所应用的血液保存技术(术前自体血捐献、等容血液稀释和机械性自体输血)旨在使大量患者在不输入异体血的情况下接受手术。
血红蛋白的基线值越高,未接受异体输血的患者人数就越多。Hb越低,血液保存技术的有效性越高。在全髋关节置换术中,术前自体血捐献在所有三组中均显著增加了未接受异体输血的患者人数。然而,在全膝关节置换术中,术前自体血捐献仅在B组和C组中显著增加了未接受异体输血的患者人数。在这两种手术中,术前自体血捐献与其他血液保存技术联合使用并未进一步增加未接受异体输血的患者人数。在全髋关节置换术中,机械性自体输血以及等容血液稀释减少了基线血红蛋白水平较低患者的异体输血。然而,当两种技术联合使用时,增加更为明显。
从我们的数据可以得出,基线血红蛋白水平较低的患者接受异体输血的可能性更大。然而,在髋关节置换术中,基线血红蛋白水平较高的患者也能从血液保存技术中获益,而在膝关节置换术中,基线血红蛋白水平较高的患者群体中血液保存技术的效率可忽略不计。针对不同类型的手术评估那些从不同血液保存技术中获益最大的患者似乎是有意义的。