N-甲基-D-天冬氨酸受体转向另一种通道进行抑制。
NMDA receptors turn to another channel for inhibition.
作者信息
Schoppa N E, Westbrook G L
机构信息
Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA.
出版信息
Neuron. 2001 Sep 27;31(6):877-9. doi: 10.1016/s0896-6273(01)00442-1.
Abstract
Activation of glutamate receptors generally increases neuronal excitability. However, Isaacson and Murphy show in olfactory bulb granule cells that NMDA receptor-mediated calcium influx couples to large conductance (BK) calcium-activated potassium channels. The resulting inhibition is long lasting, which may be critical to the operation of the dynamic circuitry of the bulb.
摘要
谷氨酸受体的激活通常会增加神经元的兴奋性。然而，艾萨克森和墨菲在嗅球颗粒细胞中发现，NMDA受体介导的钙内流与大电导（BK）钙激活钾通道耦合。由此产生的抑制作用持续时间较长，这可能对嗅球动态回路的运作至关重要。
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