沙丁胺醇对健康儿童肺功能参数的影响。

Effect of salbutamol on lung function parameters of healthy children.

作者信息

Delanghe K, Desager K N, Van Bever H P

机构信息

Department of Paediatrics, University Hospital Antwerp, Edegem-Antwerp, Belgium.

出版信息

Eur J Pediatr. 2001 Sep;160(9):576-8. doi: 10.1007/s004310100796.

DOI:10.1007/s004310100796

PMID:11585083

Abstract

UNLABELLED

In the present study, the effect of 200 microg salbutamol compared to placebo was evaluated on lung function parameters of 37 healthy children aged 7-14 years. Salbutamol or placebo were administered, using a single blind study design, and spirometry was performed before and after 10 min of inhalation. At the time of the study, all children were symptom-free and had not suffered from any respiratory infection during the previous 4 weeks. The administration of salbutamol resulted in a significant increase of mean forced expiratory volume in 1 s (111%-115%, P<0.05), maximal expiratory flow at 50% of forced vital capacity (101%-110%, P<0.05) and maximal expiratory flow at 25 % of forced vital capacity (96%-115%, P<0.05). The administration of placebo resulted in no significant change in lung function parameters.

CONCLUSION

The administration of 200 microg salbutamol results in the occurrence of a small but significant bronchodilation in healthy, non-asthmatic children.

摘要

未标注

在本研究中，对37名7至14岁健康儿童的肺功能参数评估了200微克沙丁胺醇与安慰剂相比的效果。采用单盲研究设计给予沙丁胺醇或安慰剂，并在吸入10分钟前后进行肺活量测定。在研究时，所有儿童均无症状，且在过去4周内未患任何呼吸道感染。给予沙丁胺醇导致1秒用力呼气容积显著增加（111%-115%，P<0.05）、用力肺活量50%时的最大呼气流量显著增加（101%-110%，P<0.05）以及用力肺活量25%时的最大呼气流量显著增加（96%-115%，P<0.05）。给予安慰剂导致肺功能参数无显著变化。