Synthesis and application of Fmoc-His(3-Bum)-OH.
作者信息
Mergler M, Dick F, Sax B, Schwindling J, Vorherr T H
机构信息
BACHEM AG, Bubendorf, Switzerland.
出版信息
J Pept Sci. 2001 Sep;7(9):502-10. doi: 10.1002/psc.345.
DOI:10.1002/psc.345
PMID:11587189
Abstract
This paper presents a reevaluation of the synthesis and properties of Fmoc-His(3-Bum)-OH regarding its application in SPPS with minimal racemization of histidine residues during coupling and esterification reactions. By-product formation during the deprotection of the test peptides could be significantly reduced by scavenging the concomitantly formed HCHO, e.g. with methoxyamine.
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