The dual role of CTLA-4 in Leishmania infection.
作者信息
Gomes N A, DosReis G A
机构信息
Oswaldo Cruz Institute, FIOCRUZ, Av. Brasil, 4365, Rio de Janeiro, RJ 21045-900, Brazil.
出版信息
Trends Parasitol. 2001 Oct;17(10):487-91. doi: 10.1016/s1471-4922(01)02038-4.
Abstract
The role of CTLA-4 in inducing the production of transforming growth factor beta (TGF-beta) from T cells during a Leishmania infection has only recently been recognized. However, CTLA-4 and TGF-beta affect T helper cells differently, depending on the maturation. This review discusses the data obtained from different experimental models and demonstrates that CTLA-4 is a target molecule for vaccination and therapy against leishmaniasis.
摘要
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