Iukhimenko N V
Probl Tuberk. 2001(5):19-22.
Clinical and X-ray studies were made in 148 children 2-10 years after hospital treatment to evaluate the stability of clinical recovery by the frequency of relapses in relation to the use of different drug treatment regimens. Children from an experimental group (n = 75) received shorter chemotherapy with 3-4 drugs (isoniazid, rifampicin, pyrazinamide in uncomplicated tuberculosis plus streptomycin in complicated one) in the intensive phase of chemotherapy. Pyrazinamide was not used in the intensive phase in the control group (n = 73). Long-term follow-ups showed a high efficiency of shorter chemotherapy regimens in treating intrathoracic tuberculosis in children since they do not lead to the higher incidence of recurrences--2.7% in both groups. The latter occurred in adolescents who had severe residual changes, who had been irregularly followed up at the tuberculosis control dispensary after hospital discharge, who had not received seasonal preventive chemotherapy courses, and who had experienced complicated, generalized or acute tuberculosis.
对148名接受过住院治疗的2至10岁儿童进行了临床和X线研究，以根据不同药物治疗方案的复发频率评估临床康复的稳定性。实验组（n = 75）的儿童在化疗强化期接受了3 - 4种药物的短程化疗（单纯性结核使用异烟肼、利福平、吡嗪酰胺，复杂性结核加用链霉素）。对照组（n = 73）在强化期未使用吡嗪酰胺。长期随访显示，短程化疗方案治疗儿童胸内结核效率高，因为它们不会导致更高的复发率——两组均为2.7%。复发发生在有严重残留病变的青少年中，这些青少年出院后在结核病防治所未得到定期随访，未接受季节性预防性化疗疗程，并且曾患复杂性、全身性或急性结核病。
