Kalil K
J Comp Neurol. 1979 Nov 1;188(1):43-62. doi: 10.1002/cne.901880105.
Projections from the cerebellar and dorsal column nuclei to the inferior olive of the rhesus monkey were traced with anterograde autoradiographic methods. The cerebellar nuclei give rise to a massive projection which reaches the contralateral inferior olivary complex by way of the descending limb of the superior cerebellar peduncle. Dentato-olivary fibers project exclusively upon the principal olivary nucleus (PO) and observe a strict topography. The dorsal, lateral, and ventral dentate project respectively to the dorsal, lateral, and ventral lamellae of the PO. Within the lamellae, the dentato-olivary fibers are related point for point in the medio-lateral axis. By contrast, the rostro-caudal topography is reversed so that the rostral pole of the dentate projects to the caudal PO and the caudal dentate to the rostral PO. These connections are predominantly crossed but a small ipsilateral component recrosses the midline at the olivary commissure and mirrors the topography on the opposite side. The anterior interpositus projects only to the medial half of the DAO and the posterior interpositus projects only to the rostral two thirds of the MAO. The ipsilateral component is minor in comparison with the contralateral projection, but appears to be more substantial than the ipsilateral projection to the PO arising from the dentate nucleus. The fastigial nucleus does not project upon the olivary complex. The dorsal column nuclei project topographically upon the contralateral accessory nuclei with the gracile nucleus sending fibers primarily to the lateral half of the DAO and the cuneate nucleus projecting to rostral cell groups of the MAO. The present results when compared with other olivary connections described by previous studies in a variety of species suggest that regions of the MAO and DAO receiving sensory information from the periphery may lie outside the influence of cerebellar feedback loops.
采用顺行性放射自显影法追踪了恒河猴小脑核和薄束核至下橄榄核的投射。小脑核发出大量投射纤维，经小脑上脚的下行支到达对侧下橄榄复合体。齿状核-橄榄纤维仅投射至主橄榄核（PO），并呈现严格的拓扑结构。齿状核的背侧、外侧和腹侧分别投射至PO的背侧、外侧和腹侧薄片。在薄片内，齿状核-橄榄纤维在中外侧轴上点对点对应。相比之下，前后拓扑结构相反，即齿状核的嘴侧极投射至PO的尾侧，而齿状核的尾侧投射至PO的嘴侧。这些连接主要是交叉性的，但一小部分同侧成分在橄榄连合处再次交叉中线，并与对侧的拓扑结构镜像对应。前间位核仅投射至背侧副橄榄核的内侧半，后间位核仅投射至内侧副橄榄核嘴侧的三分之二。与对侧投射相比，同侧成分较少，但似乎比对侧齿状核投射至PO的同侧投射更显著。顶核不投射至橄榄复合体。薄束核按拓扑结构投射至对侧副核，薄束核主要将纤维发送至背侧副橄榄核的外侧半，楔束核投射至内侧副橄榄核嘴侧的细胞群。将本研究结果与以往在多种物种中描述的其他橄榄核连接进行比较，结果表明，内侧副橄榄核和背侧副橄榄核中接收来自外周感觉信息的区域可能不受小脑反馈回路的影响。
