西洛他唑对非胰岛素依赖型糖尿病大鼠模型糖耐量和胰岛素抵抗的影响。
The effect of cilostazol on glucose tolerance and insulin resistance in a rat model of non-insulin dependent diabetes mellitus.
作者信息
Chang S A, Cha B Y, Yoo S J, Ahn Y B, Song K H, Han J H, Lee J M, Son H S, Yoon K H, Kang M I, Lee K W, Son H Y, Kang S K
机构信息
Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.
出版信息
Korean J Intern Med. 2001 Jun;16(2):87-92. doi: 10.3904/kjim.2001.16.2.87.
BACKGROUND
It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined.
METHODS
About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats.
RESULTS
In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats.
CONCLUSION
These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.
背景
据报道，许多外周血管扩张药物可能会改善胰岛素抵抗。西洛他唑是一种抗血栓药物，可增加非胰岛素依赖型糖尿病患者的外周血流量。本研究检测了西洛他唑治疗对链脲佐菌素（STZ）诱导的非胰岛素依赖型糖尿病Wistar大鼠胰岛素抵抗的影响。
方法
将约一半2日龄的新生仔鼠腹腔注射STZ并饲养6个月，此时对其进行腹腔葡萄糖耐量试验（IPGTT）以及正常血糖高胰岛素葡萄糖钳夹研究中的葡萄糖输注率（GINF）测定，并与年龄匹配的对照大鼠进行比较。之后，对STZ诱导的非胰岛素依赖型糖尿病大鼠喂食含西洛他唑（100 mg/kg/天）的大鼠饲料4周后，再进行上述研究，并与年龄匹配的对照大鼠进行比较。
结果
在腹腔葡萄糖耐量试验研究中，6个月龄时，STZ诱导的非胰岛素依赖型糖尿病大鼠的血浆葡萄糖水平显著高于年龄匹配的对照大鼠，而血浆胰岛素水平显著低于对照大鼠。STZ诱导的非胰岛素依赖型糖尿病大鼠的葡萄糖输注率低于年龄匹配的对照大鼠。然而，经过4周的西洛他唑治疗后，STZ诱导的非胰岛素依赖型糖尿病大鼠的葡萄糖输注率与对照大鼠无显著差异。
结论
这些发现表明，西洛他唑可能改善STZ诱导的非胰岛素依赖型糖尿病大鼠的胰岛素抵抗。
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