突触可塑性：一种分子记忆开关。
Synaptic plasticity: a molecular memory switch.
作者信息
Lisman J E, McIntyre C C
机构信息
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02453, USA.
出版信息
Curr Biol. 2001 Oct 2;11(19):R788-91. doi: 10.1016/s0960-9822(01)00472-9.
Abstract
Recent work shows that two molecules with major roles in synaptic plasticity--CaMKII and the NMDA receptor--bind to each other. This binding activates CaMKII and triggers its autophosphorylation. In this state, it may act as a memory switch and strengthen synapses through enzymatic and structural processes.
摘要
最近的研究表明，在突触可塑性中起主要作用的两种分子——钙/钙调蛋白依赖性蛋白激酶II（CaMKII）和N-甲基-D-天冬氨酸受体（NMDA受体）——相互结合。这种结合激活了CaMKII并触发其自身磷酸化。在这种状态下，它可能充当记忆开关，并通过酶促和结构过程增强突触。
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