前沿：白细胞介素-17F，一种在活化T细胞和单核细胞中选择性表达的新型细胞因子，可调节血管生成和内皮细胞细胞因子的产生。

Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production.

作者信息

Starnes T, Robertson M J, Sledge G, Kelich S, Nakshatri H, Broxmeyer H E, Hromas R

机构信息

Department of Medicine and Biochemistry, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA.

出版信息

J Immunol. 2001 Oct 15;167(8):4137-40. doi: 10.4049/jimmunol.167.8.4137.

DOI:10.4049/jimmunol.167.8.4137

PMID:11591732

Abstract

A novel secreted cytokine, termed IL-17F, was cloned using nested RACE PCR. This cytokine bears homology to IL-17. IL-17F was expressed only in activated CD4(+) T cells and activated monocytes. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattractant protein-1.

摘要

一种名为IL-17F的新型分泌细胞因子通过巢式RACE PCR克隆得到。这种细胞因子与IL-17具有同源性。IL-17F仅在活化的CD4(+) T细胞和活化的单核细胞中表达。重组人IL-17F不刺激造血祖细胞的增殖或成熟白细胞的迁移。然而，它显著抑制人内皮细胞的血管生成，并诱导内皮细胞产生IL-2、转化生长因子-β和单核细胞趋化蛋白-1。