重组神经生长因子用于治疗HIV相关感觉神经病变的长期治疗

Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy.

作者信息

Schifitto G, Yiannoutsos C, Simpson D M, Adornato B T, Singer E J, Hollander H, Marra C M, Rubin M, Cohen B A, Tucker T, Koralnik I J, Katzenstein D, Haidich B, Smith M E, Shriver S, Millar L, Clifford D B, McArthur J C

机构信息

Department of Neurology, University of Rochester, NY 14642, USA.

出版信息

Neurology. 2001 Oct 9;57(7):1313-6. doi: 10.1212/wnl.57.7.1313.

DOI:10.1212/wnl.57.7.1313

PMID:11591856

Abstract

HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.

摘要

人类免疫缺陷病毒相关的远端感觉性多发性神经病（DSP）是艾滋病的常见并发症。目前尚无有效的治疗方法。作者在一项针对200例人类免疫缺陷病毒相关DSP患者的开放标签研究中，研究了神经营养因子神经生长因子（NGF）的长期疗效（48周）。与他们之前报道的双盲研究相似，作者表明NGF安全且耐受性良好，并能显著改善疼痛症状。然而，通过神经学检查、定量感觉测试和表皮神经纤维密度评估，神经病变严重程度并未改善。