肝移植前后腰椎和股骨颈骨密度的系列变化评估。

Assessment of serial changes of bone mineral density at lumbar spine and femoral neck before and after liver transplantation.

作者信息

Xu H, Eichstaedt H

机构信息

Department of Nuclear Medicine, Affiliated Hospital, Jinan University Medical College, Guangzhou 510630, China.

出版信息

Chin Med J (Engl). 1999 Apr;112(4):379-81.

PMID:11593545

Abstract

OBJECTIVE

To assess serial changes of bone mass before and after orthotopic liver transplantation (OLT).

METHODS

Consecutive bone mineral density (BMD) of lumbar spine (L2-L4) and femoral neck in 38 patients with chronic liver failure within 2 months before OLT, 6, 12 and 24 months after OLT was determined using dual energy X-ray absorptiometry.

RESULTS

29% of 38 patients before OLT had osteoporosis (BMD below 2 standard deviate). BMD levels at L2-L4 and femoral neck decreased and incidence of osteoporosis increased in the first 6 months after OLT. Over beyond 6 months post-OLT BMD levels at L2-L4 increased to just slightly above the pretransplant level and incidence of osteoporosis decreased from 36.8% (6 months after OLT) to 7.9% (24 months after OLT). Although BMD levels at femoral neck by 12 and 24 months after OLT gradually increased, BMD levels at femoral neck were still lower than those before OLT.

CONCLUSIONS

There was already a low bone mass in patients with chronic liver disease before OLT and liver transplantation induced a marked and rapid bone loss.

摘要

目的

评估原位肝移植（OLT）前后骨量的系列变化。

方法

采用双能X线吸收法测定38例慢性肝功能衰竭患者在OLT前2个月内、OLT后6、12和24个月时腰椎（L2-L4）和股骨颈的连续骨密度（BMD）。

结果

38例患者中，29%在OLT前患有骨质疏松症（BMD低于2个标准差）。OLT后前6个月，L2-L4和股骨颈的BMD水平下降，骨质疏松症的发生率增加。OLT后6个月以上，L2-L4的BMD水平升至略高于移植前水平，骨质疏松症的发生率从36.8%（OLT后6个月）降至7.9%（OLT后24个月）。虽然OLT后12个月和24个月时股骨颈的BMD水平逐渐升高，但股骨颈的BMD水平仍低于OLT前。