Chen X, Long D, Wang S
Department of Plastic Surgery, First Affiliated Hospital of Hubei Medical University, Wuhan 430060, PR China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2000 Mar;16(2):105-7.
To study the role of sex hormone receptor capacity of the scalp in male pattern baldness(MPB).
Estrogen receptor(ER) and androgen receptor(AR) assays were performed using fluorescent steroid hormone conjugate technique (FSHCT) in hairness and bald scalp in 8 patients with MPB. Changes of ER and AR capacity in recipient and donor sites of hair transplantation in MPB scalps were examined.
The percentage of AR staining cells in the outer root sheath, sebaceous gland and bulb papilla of the lesional scalps was significantly higher than that of hairness scalps (P < 0.01). The percentage of ER positive cells in the outer root sheath of lesional scalps increased significantly (P < 0.01).
Changes of contents of sex hormone receptors(SHR) in some sensitive area of the scalp induce MPB.
研究头皮性激素受体容量在男性型秃发（MPB）中的作用。
采用荧光类固醇激素结合技术（FSHCT）对8例MPB患者的有发头皮和秃发头皮进行雌激素受体（ER）和雄激素受体（AR）检测。观察MPB头皮毛发移植受区和供区ER和AR容量的变化。
病变头皮外根鞘、皮脂腺和毛乳头中AR染色细胞百分比显著高于有发头皮（P < 0.01）。病变头皮外根鞘中ER阳性细胞百分比显著增加（P < 0.01）。
头皮某些敏感区域性激素受体（SHR）含量的变化诱发MPB。
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