Watroba L, Buser P, Milleret C
Laboratoire de Physiologie de la Perception et de l'Action, UMR CNRS 9950, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France.
Eur J Neurosci. 2001 Sep;14(6):1021-9. doi: 10.1046/j.0953-816x.2001.01720.x.
In the primary visual cortex of normally reared adult cat, neurons activated through the corpus callosum are almost entirely located at the 17/18 border. They display small receptive fields distributed along the central vertical meridian of the visual field and are orientation selective. Here we demonstrate that a few weeks of monocular deprivation or unilateral convergent strabismus produced in adulthood does not modify the cortical distribution of these neurons, but leads to an increase of their receptive field size mainly toward the ipsilateral hemifield and to a loss of their orientation selectivity. We conclude that manipulation of binocular vision in the adult modifies neither the location of the primary callosal cortical map nor its retinotopy. In contrast, it induces functional plastic changes in this map which lead to a significant widening of the area of visual space signalled through the corpus callosum. These plastic changes are interpreted as the result of the strengthening of normally hidden subthreshold synaptic inputs.
在正常饲养的成年猫的初级视皮层中，通过胼胝体激活的神经元几乎全部位于17/18边界。它们具有沿视野中央垂直子午线分布的小感受野，并且具有方向选择性。在这里我们证明，成年期产生的几周单眼剥夺或单侧会聚性斜视不会改变这些神经元的皮层分布，但会导致其感受野大小主要向同侧半视野增加，并导致其方向选择性丧失。我们得出结论，成年期双眼视觉的操纵既不会改变初级胼胝体皮层图谱的位置，也不会改变其视网膜拓扑结构。相反，它会在该图谱中诱导功能性可塑性变化，导致通过胼胝体发出信号的视觉空间区域显著扩大。这些可塑性变化被解释为通常隐藏的阈下突触输入增强的结果。
