核因子-κB p50在分枝杆菌感染中的相对重要性
Relative importance of NF-kappaB p50 in mycobacterial infection.
作者信息
Yamada H, Mizuno S, Reza-Gholizadeh M, Sugawara I
机构信息
Department of Molecular Pathology, The Research Institute of Tuberculosis, Tokyo 204-0022, Japan.
出版信息
Infect Immun. 2001 Nov;69(11):7100-5. doi: 10.1128/IAI.69.11.7100-7105.2001.
Abstract
To understand the role of NF-kappaB in the development of murine tuberculosis in vivo, NF-kappaB p50 knockout mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne-infection apparatus. These mice developed multifocal necrotic pulmonary lesions or lobar pneumonia. Compared with the levels in wild-type mice, pulmonary inducible nitric oxide synthase, interleukin-2 (IL-2), gamma interferon, and tumor necrosis factor alpha mRNA levels were significantly low but expression of IL-10 and transforming growth factor beta mRNAs were within the normal ranges. The pulmonary IL-6 mRNA expression level was higher. Therefore, NF-kappaB and its interaction with host cells play an important role in the pathogenesis of tuberculosis.
摘要
为了解核因子-κB（NF-κB）在小鼠体内结核分枝杆菌感染发展过程中的作用，将NF-κB p50基因敲除小鼠置于空气传播感染装置的暴露室中，使其感染结核分枝杆菌。这些小鼠出现了多灶性坏死性肺部病变或大叶性肺炎。与野生型小鼠相比，肺诱导型一氧化氮合酶、白细胞介素-2（IL-2）、γ干扰素和肿瘤坏死因子α的mRNA水平显著降低，但IL-10和转化生长因子β的mRNA表达在正常范围内。肺IL-6 mRNA表达水平较高。因此，NF-κB及其与宿主细胞的相互作用在结核病发病机制中起重要作用。
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