Ayerbe M C, Pérez-Rivilla A
Department of Public Health Service, Gerencia Atención Primaria Area Sanitaria 8 of Madrid, Spain.
Eur J Epidemiol. 2001;17(2):150-6. doi: 10.1023/a:1017922302854.
In a healthy cohort of 462 subjects in which hepatitis B vaccine was administered between 1990 and 1992 a follow-up study was carried out to determine the duration of protection. Individuals with antibody against the hepatitis B virus surface antigen (anti-HBs) titer lower than 100 mIU/ml were administered a booster dose and antibodies determined 30 days later. The proportion of protection 6.5 years after vaccination was 85% (95% CI: 82-88). Only nine vaccinees seroconverted to anti-HBc positivity without becoming carrier or ill. In 125 subjects in which a booster dose was administered a significant increase in geometric mean of anti-HBs titer was observed (609 mIU/ml) as compared to late (13 mlU/ ml) and early post-vaccination antibody levels (256 mIU/ml, Wilcoxon's test, p < 0.001) suggesting the existence of an anamnestic response. We conclude that in immunocompetent population it is not necessary to administer a booster dose 6.5 years after hepatitis B vaccination.
在1990年至1992年间接种了乙肝疫苗的462名健康受试者队列中，开展了一项随访研究以确定保护期。对乙肝病毒表面抗原抗体（抗-HBs）滴度低于100 mIU/ml的个体给予加强剂量，并在30天后测定抗体。接种疫苗6.5年后的保护比例为85%（95%置信区间：82-88）。只有9名接种者血清转化为抗-HBc阳性，但未成为携带者或患病。在125名接受加强剂量的受试者中，观察到抗-HBs滴度的几何平均值显著升高（609 mIU/ml），与接种疫苗后期（13 mIU/ml）和早期抗体水平（256 mIU/ml）相比（Wilcoxon检验，p<0.001），提示存在回忆反应。我们得出结论，在免疫功能正常的人群中，乙肝疫苗接种6.5年后无需给予加强剂量。
