Qian K, Zeng P, Ru W, Yuan H, Feng Z, Li L
Institute of Biomedical Engineering, Jiangsu University of Science & Technology, Zhenjiang 212013.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2001 Sep;18(3):391-3.
As is well known, a pulsatile flow is important in assisted-circulation but it is difficult to produce a pulsatile flow with rotary pump, because excessive hemolysis will be generated. The authors have found that the turbulent shear is the main factor for red cell damage and therefore the key point of pulsatile rotary pumps is to reduce the turbulence by producing a pulsatile flow. In the authors' pulsatile axial pump, the pulsatile flow is obtained by axial reciprocation of constant rotating impeller; the rotation and reciprocation of the impeller are driven separately by a DC motor and a pneumatic device. Though a physiological pulsatile flow could be achieved and turbulence would not increase remarkably because the impeller rotates constantly, a second driver except a DC motor is nevertheless necessary, thus the system will become complicated. In the authors' pulsatile radial pump, a pulsatile flow is achieved by changing the rotating speed of the impeller periodically. Turbulence is minimized by a special design of twisted vanes which enable the blood flow to change its direction rather than its dimension during periodic change of rotating speed. Hemolysis tests demonstrated that the index of hemolysis(IH) of the author's pulsatile radial pump is 0.020, with is slightly more than that of the author's nonpulsatile radial pump(IH = 0.015). Animal experiments indicated that the pulsatile radial pump can assist the circulation of calves for several months without harm to blood elements and organ functions of the recipients.
众所周知,搏动性血流在辅助循环中很重要,但用旋转泵产生搏动性血流很困难,因为会产生过多的溶血。作者发现湍流切变是红细胞损伤的主要因素,因此搏动性旋转泵的关键在于通过产生搏动性血流来减少湍流。在作者的搏动性轴流泵中,搏动性血流是通过恒速旋转的叶轮轴向往复运动获得的;叶轮的旋转和往复运动分别由直流电机和气动装置驱动。虽然可以实现生理性搏动性血流,并且由于叶轮持续旋转湍流不会显著增加,但除了直流电机外仍需要第二个驱动器,因此系统会变得复杂。在作者的搏动性径流泵中,通过周期性改变叶轮的转速来实现搏动性血流。通过特殊设计的扭曲叶片将湍流降至最低,这种叶片能使血流在转速周期性变化期间改变方向而非尺寸。溶血试验表明,作者的搏动性径流泵的溶血指数(IH)为0.020,略高于作者的非搏动性径流泵(IH = 0.015)。动物实验表明,搏动性径流泵可以辅助小牛循环数月,而不会损害受体的血液成分和器官功能。