[同源结构域与DNA相互作用的结构方面]

[Structural aspects of homeodomain interactions with DNA].

作者信息

Ledneva R K, Alekseevskiĭ A V, Vasil'ev S A, Spirin S A, Kariagina A S

出版信息

Mol Biol (Mosk). 2001 Sep-Oct;35(5):764-77.

Abstract

This review is devoted to the structural aspects of interaction of homeodomains with DNA. Presented are the list of all homeodomains with known spatial structure and the alignment of their amino acid sequences. The structure of homeodomains and contacts of their amino acid residues with DNA bases and sugar-phosphate backbone are described. The role of water molecules in DNA binding is discussed. Structures of multicomponent protein complexes on DNA including homeodomains are characterized.

摘要

本综述致力于同源结构域与DNA相互作用的结构方面。列出了所有已知空间结构的同源结构域及其氨基酸序列比对。描述了同源结构域的结构及其氨基酸残基与DNA碱基和糖磷酸骨架的接触。讨论了水分子在DNA结合中的作用。对包括同源结构域在内的DNA上多组分蛋白质复合物的结构进行了表征。