Song J S, Park W, Bae S K, Kim S S, Lee Y H, Choi J W, Kim S K
Department of Rheumatology/Medicine, Inha University School of Medicine, Inchon, Republic of Korea.
Rheumatol Int. 2001 Sep;21(1):24-9. doi: 10.1007/s002960100128.
This study was aimed at investigating the usefulness of serum transferrin receptor (sTfR) and ferritin in anemic patients with rheumatoid arthritis (RA) compared with bone marrow storage iron and other tests for anemia.
Fifty-five anemic RA patients underwent anemia study. Bone marrow iron stain was performed in 18 patients. sTfR and serum ferritin levels were compared with bone marrow iron stores.
(1) Mean sTfR concentration was 2.63+/-1.91 mg/L, (2) sTfR correlated with most indicators of anemia, (3) sTfR showed no correlation with CRP and ESR, whereas ferritin did, and (4) sTfR was higher in the "iron depleted" subgroup than in the "iron nondepleted" subgroup in bone marrow study.
The measurement of sTfR and ferritin is useful in finding the cause of anemia in RA and is a possible substitute for invasive bone marrow iron study.
本研究旨在探讨血清转铁蛋白受体（sTfR）和铁蛋白在类风湿关节炎（RA）贫血患者中的作用，并与骨髓储存铁及其他贫血检查方法进行比较。
55例RA贫血患者接受了贫血研究。18例患者进行了骨髓铁染色。将sTfR和血清铁蛋白水平与骨髓铁储存情况进行比较。
（1）sTfR平均浓度为2.63±1.91mg/L，（2）sTfR与大多数贫血指标相关，（3）sTfR与CRP和ESR无相关性，而铁蛋白有相关性，（4）在骨髓研究中，“缺铁”亚组的sTfR高于“非缺铁”亚组。
sTfR和铁蛋白的检测有助于发现RA贫血的病因，可能替代有创的骨髓铁研究。
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