与人类SOX30 HMG盒同源的微蝙蝠HMG盒序列。

HMG-box sequences from microbats homologous to the human SOX30 HMG-box.

作者信息

Bullejos M, Díaz de la Guardia R, Barragán M J, Sánchez A

机构信息

Departamento de Biología Experimental, Facultad de Ciencias Experimentales, Universidad de Jaén, Spain.

出版信息

Genetica. 2000;110(2):157-62. doi: 10.1023/a:1017914005677.

DOI:10.1023/a:1017914005677

PMID:11678506

Abstract

SOX genes are a family of genes that encode for proteins which are characterised by the presence of a HMG-domain related to that of the mammalian sex-determining gene (SRY). By definition, the DNA binding domain of SOX genes is at least 50% identical to the 79 amino acid HMG domain of the SRY gene. We report here two HMG-box sequences from two microbat species (R. ferrumequinum and P. Pipistrellus) which were PCR amplified using a primer pair specific to the mouse Sry HMG-box. The high percentage of identity of this sequences with the human and mouse SOX30 HMG-box suggests that they are the SOX30 HMG-box for these two bat species.

摘要

SOX基因是一个基因家族，其编码的蛋白质的特征是存在与哺乳动物性别决定基因（SRY）相关的HMG结构域。根据定义，SOX基因的DNA结合结构域与SRY基因的79个氨基酸的HMG结构域至少有50%的同一性。我们在此报告了来自两种小型蝙蝠物种（马铁菊头蝠和普通伏翼）的两个HMG盒序列，它们是使用针对小鼠Sry HMG盒的引物对通过PCR扩增得到的。这些序列与人类和小鼠SOX30 HMG盒的高同一性百分比表明，它们是这两种蝙蝠物种的SOX30 HMG盒。