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胰十二指肠切除术后再入院情况。

Readmissions after pancreatoduodenectomy.

作者信息

van Geenen R C, van Gulik T M, Busch O R, de Wit L T, Obertop H, Gouma D J

机构信息

Department of Surgery, Academic Medical Center, Meibergdreef 9, PO Box 22660, 1100 DD Amsterdam, The Netherlands.

出版信息

Br J Surg. 2001 Nov;88(11):1467-71. doi: 10.1046/j.0007-1323.2001.01900.x.

Abstract

BACKGROUND

Readmission after pancreatoduodenectomy because of tumour recurrence or surgery-related complications can adversely affect patient outcome.

METHODS

From October 1992 to June 1999, 283 consecutive resections were performed (243 for malignant disease and 40 for benign disease). The hospital mortality rate was 1 per cent (three of 283). All readmissions were analysed with regard to indication, treatment and outcome.

RESULTS

One hundred and six patients (38 per cent) were readmitted, 64 (60 per cent) because of tumour recurrence and indications such as gastrointestinal obstruction (n = 19), biliary obstruction (n = 15) and pain (n = 21), of whom 30 patients (47 per cent) were in a preterminal condition. Median hospital stay and hospital-free survival after discharge were 14 and 51 days respectively. Median survival after surgical treatment (n = 14) was 58 days, and ascites was significantly associated with poor survival. Forty-seven (44 per cent) of the patients were readmitted for surgical complications such as abscess (n = 11), fistula (n = 8) and gastrointestinal obstruction (n = 8). Median hospital stay was 15 days and median hospital-free survival after discharge was 1035 days.

CONCLUSION

Readmission after pancreatoduodenectomy was common (38 per cent), 60 per cent for tumour recurrence and 44 per cent for surgery-related complications. Survival after surgical bypass procedures for tumour recurrence was limited, particularly when ascites was present. Patients readmitted for complications of surgery had a good prognosis.

摘要

背景

胰十二指肠切除术后因肿瘤复发或手术相关并发症再次入院会对患者预后产生不利影响。

方法

1992年10月至1999年6月,连续进行了283例切除术(243例为恶性疾病,40例为良性疾病)。医院死亡率为1%(283例中有3例)。对所有再次入院情况进行了指征、治疗及预后分析。

结果

106例患者(38%)再次入院,64例(60%)因肿瘤复发及诸如胃肠道梗阻(19例)、胆道梗阻(15例)和疼痛(21例)等指征,其中30例患者(47%)处于终末期前状态。再次入院后的中位住院时间和出院后无住院生存期分别为14天和51天。手术治疗后(14例)的中位生存期为58天,腹水与生存不良显著相关。47例(44%)患者因手术并发症如脓肿(11例)、瘘(8例)和胃肠道梗阻(8例)再次入院。中位住院时间为15天,出院后中位无住院生存期为1035天。

结论

胰十二指肠切除术后再次入院很常见(38%),肿瘤复发占60%,手术相关并发症占44%。肿瘤复发行手术旁路术后的生存期有限,尤其是存在腹水时。因手术并发症再次入院的患者预后良好。

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