胆汁淤积大鼠的条件性味觉厌恶与c-Fos表达

Conditioned taste aversion and c-Fos expression in cholestatic rats.

作者信息

Na E S, Fitts D A

机构信息

Department of Psychology, University of Washington, Seattle, WA 98195-1525, USA.

出版信息

Brain Res. 2001 Nov 9;918(1-2):187-90. doi: 10.1016/s0006-8993(01)02982-1.

DOI:10.1016/s0006-8993(01)02982-1

PMID:11684058

Abstract

Rats in which a ligation of the bile duct (BDL) was paired with a saccharin taste developed a persistent conditioned taste aversion in both preference and taste reactivity tests. All BDL animals regardless of pairing had increased c-Fos-like immunoreactivity (FLI) in the area postrema and the nucleus of the solitary tract. This FLI may reflect the illness associated with BDL, but there was no evidence of conditioned FLI.

摘要

将胆管结扎（BDL）与糖精味觉配对的大鼠在偏好和味觉反应性测试中均出现了持续的条件性味觉厌恶。所有胆管结扎动物，无论是否配对，其最后区和孤束核中的c-Fos样免疫反应性（FLI）均增加。这种FLI可能反映了与胆管结扎相关的疾病，但没有条件性FLI的证据。