早期结直肠癌中低水平微卫星不稳定性的高发生率。
High frequency of low-level microsatellite instability in early colorectal cancer.
作者信息
Kambara T, Matsubara N, Nakagawa H, Notohara K, Nagasaka T, Yoshino T, Isozaki H, Sharp G B, Shimizu K, Jass J, Tanaka N
机构信息
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Okayama 700-8558, Japan.
出版信息
Cancer Res. 2001 Nov 1;61(21):7743-6.
Molecular events in early colorectal cancers (CRCs) have not been well elucidated because of the low incidence of early CRCs in clinical practice. Therefore, we studied 104 sporadic early CRCs with invasion limited to submucosa compared with 116 advanced CRCs. Loss of heterozygosity as well as microsatellite instability (MSI) status was examined. A significantly high frequency of low-level MSI (MSI-L) phenotype was detected in early CRCs (51.0%) compared with advanced CRCs (25.9%; P = 0.0001). In early and advanced CRCs, samples with MSI-L phenotype differed from microsatellite stable (MSS) phenotype with respect to loss of heterozygosity at 1p32 and 8p12-22. MSI-L is a frequent genetic event in early CRCs and may be a novel pathway in colorectal carcinogenesis distinct from both MSI-H and MSS.
由于临床实践中早期结直肠癌（CRC）的发病率较低，其分子事件尚未得到充分阐明。因此，我们研究了104例浸润局限于黏膜下层的散发性早期CRC，并与116例晚期CRC进行比较。检测了杂合性缺失以及微卫星不稳定性（MSI）状态。与晚期CRC（25.9%；P = 0.0001）相比，早期CRC中检测到低水平MSI（MSI-L）表型的频率显著较高（51.0%）。在早期和晚期CRC中，MSI-L表型的样本在1p32和8p12-22处的杂合性缺失方面与微卫星稳定（MSS）表型不同。MSI-L是早期CRC中常见的遗传事件，可能是结直肠癌发生中不同于MSI-H和MSS的新途径。
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