Kakimoto S, Houtani T, Sato K, Ueyama T, Sakuma S, Munemoto Y, Ohishi H, Kase M, Yamashita T, Takeshima H, Sugimoto T
Department of Anatomy and Brain Science, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan.
Neurosci Lett. 2001 Nov 13;314(1-2):37-40. doi: 10.1016/s0304-3940(01)02272-8.
Nociceptin peptide-receptor system is known to be essential for the regulation of hearing ability. The mRNA for nociceptin precursor protein is highly expressed in the brainstem. We explored a detailed hybridohistochemical expression pattern of the nociceptin precursor mRNA in the mouse brainstem, and identified positive cells in several auditory brainstem nuclei. Positive cells were seen in the dorsal and ventral nuclei of the lateral lemniscus, the rostral periolivary region, the lateroventral and medioventral periolivary nuclei, the dorsal periolivary region, the superior paraolivary nucleus, and the external cortex and dorsal cortex of the inferior colliculus. Of these, the medioventral and lateroventral periolivary nuclei, the major sites of origin of olivocochlear bundle, were most populated by positive cells.
已知痛敏肽肽-受体系统对听力调节至关重要。痛敏肽前体蛋白的mRNA在脑干中高度表达。我们探究了小鼠脑干中痛敏肽前体mRNA详细的杂交组织化学表达模式，并在几个听觉脑干核中鉴定出阳性细胞。在外侧丘系背核和腹核、橄榄前区、外侧腹侧和内侧腹侧橄榄核、橄榄背侧区、上橄榄旁核以及下丘的外侧皮质和背侧皮质中可见阳性细胞。其中，内侧腹侧和外侧腹侧橄榄核作为橄榄耳蜗束的主要起源部位，阳性细胞数量最多。
