Schwenn O, Xia N, Krummenauer F, Dick H B
Universitäts-Augenklinik Mainz, Langenbeckstrasse 1, 55131 Mainz.
Ophthalmologe. 2001 Oct;98(10):934-43. doi: 10.1007/s003470170040.
To compare the ocular hypotensive effect of different antiglaucomatous eye drops.
This double-blind, randomized study included 119 eyes of 119 patients without other ocular pathology undergoing standardized (one surgeon, Healon) small incision cataract surgery with foldable intraocular lens implantation. The patients were assigned to one of five groups: group 1: 0.25% timolol in Gelrite (extended efficacy, n = 23); group 2: 2% dorzolamide (n = 24); group 3: combination of 0.5% timolol plus 2% dorzolamide (n = 22); group 4: brimonidine (n = 26); group 5: gentamicin (control, n = 24). Intraocular pressure (IOP) was measured preoperatively and at 3 +/- 1, 6 +/- 1, 9 +/- 1, 24 +/- 3, and 48 +/- 3 h postoperatively. Statistical interference was determined by nonparametric group comparisons using Wilcoxon's tests. Absolute values (static comparison) and intraindividual differences from preoperative measurements (dynamic comparisons) were evaluated. All p values should be regarded as descriptive values since they were not formally adjusted for multiplicity. A p value lower than 0.05 therefore indicates local statistical significance.
There were no differences between the groups with regard to age, phacoemulsification time, axial length, and preoperative IOP. A statistically significant IOP decrease was measured in group 1 at 24 (p = 0.028) and 48 h (p = 0.007) and in group 3 at 3 (p = 0.001), 6 (p = 0.001), 24 (p = 0.001), and 48 h (p = 0.001) after surgery. A statistically significant IOP increase occurred in group 4 at 3 (p = 0.001), 6 (p = 0.001), and 9 h (p = 0.001) and in group 5 at 3 (p = 0.001), 6 (p = 0.001), 9 (p = 0.001), and 24 h (p = 0.002) postoperatively. Groups 1, 2, and 3 demonstrated lower IOPs at different time points in comparison to groups 4 and 5. Furthermore, group 3 had lower IOPs at 3 h (compared to group 1) and at 6 h (compared to group 2) postoperatively. No statistical differences in IOP were found after 48 h.
The results favor a combination of 0.5% timolol plus 2% dorzolamide to control postoperative IOP elevation.
比较不同抗青光眼滴眼液的降眼压效果。
这项双盲、随机研究纳入了119例无其他眼部病变的患者的119只眼睛，这些患者均接受了标准化（由一位外科医生操作，使用Healon）的小切口白内障手术并植入可折叠人工晶状体。患者被分为五组：第1组：凝胶基质中含0.25%噻吗洛尔（长效，n = 23）；第2组：2%多佐胺（n = 24）；第3组：0.5%噻吗洛尔加2%多佐胺联合用药（n = 22）；第4组：溴莫尼定（n = 26）；第5组：庆大霉素（对照组，n = 24）。术前及术后3±1、6±1、9±1、24±3和48±3小时测量眼压（IOP）。采用Wilcoxon检验进行非参数组间比较以确定统计学干扰。评估绝对值（静态比较）以及与术前测量值的个体内差异（动态比较）。所有p值仅作为描述性值，因为未针对多重性进行正式调整。因此，p值低于0.05表明具有局部统计学意义。
各组在年龄、超声乳化时间、眼轴长度和术前眼压方面无差异。第1组在术后24小时（p = 0.028）和48小时（p = 0.007）以及第3组在术后3小时（p = 0.001）、6小时（p = 0.001）、24小时（p = 0.001）和48小时（p = 0.001）眼压有统计学意义的降低。第4组在术后3小时（p = 0.001）、6小时（p = 0.001）和9小时（p = 0.001）以及第5组在术后3小时（p = 0.001）、6小时（p = 0.001）、9小时（p = 0.001）和24小时（p = 0.002）眼压有统计学意义的升高。与第4组和第5组相比，第1、2和3组在不同时间点眼压较低。此外，第3组在术后3小时（与第1组相比）和6小时（与第2组相比）眼压更低。48小时后眼压未发现统计学差异。
结果表明0.5%噻吗洛尔加2%多佐胺联合用药有助于控制术后眼压升高。
Zotero 插件