大剂量甲氨蝶呤用于睾丸非霍奇金淋巴瘤患者孤立性中枢神经系统复发的治疗

High-dose methotrexate for isolated central nervous system relapse in patients with testicular non-Hodgkin's lymphoma.

作者信息

Batchelor T, Leahy N, Kaufman D

机构信息

Brain Tumor Center, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

出版信息

Clin Lymphoma. 2001 Sep;2(2):116-9; discussion 120-2. doi: 10.3816/clm.2001.n.017.

DOI:10.3816/clm.2001.n.017

PMID:11707852

Abstract

Four consecutive patients with testicular non-Hodgkin's lymphoma who initially achieved a complete response to treatment with standard combination therapy later developed isolated central nervous system (CNS) relapses. At the time of CNS relapse, staging evaluations were negative for lymphoma outside the nervous system in all 4 patients. These patients were treated with high-dose intravenous methotrexate alone, and a complete remission was achieved in all 4 patients.

摘要

4例睾丸非霍奇金淋巴瘤患者最初对标准联合治疗取得完全缓解，但随后均出现孤立性中枢神经系统（CNS）复发。在CNS复发时，所有4例患者神经系统外淋巴瘤的分期评估均为阴性。这些患者仅接受了大剂量静脉注射甲氨蝶呤治疗，所有4例患者均实现了完全缓解。