dl-四氢巴马汀对大鼠的低温作用
The hypothermic effects of dl-tetrahydropalmatine in rats.
作者信息
Lin M T, Chueh F Y, Hsieh M T
机构信息
Department of Medical Research, Chi-Mei Medical Center, Yung-Kang City, 710, Tainan Hsien, Taiwan.
出版信息
Neurosci Lett. 2001 Nov 23;315(1-2):53-6. doi: 10.1016/s0304-3940(01)02323-0.
Systemic administration of dl-tetrahydropalmatine (THP; 10-50 mg x kg(-1) intraperitoneally) produced a proportional decrease in both colonic temperature and release of hypothalamic serotonin (5-hydroxytryptamine (5-HT)) in rats at room temperature. The hypothermia was brought about by cutaneous vasodilation and decreased metabolism. The THP- induced hypothermia was significantly attenuated in rats with brain 5-HT depletion produced by control injection of 5,7-dihydroxytryptamine or in rats with 5-HT2A receptor activation produced by 1-(2,5-dimethoxy-4-iodophenyl) -2-aminopropane, or in rats with 5-HT1A receptor antagonist produced by (-)-pindolol. The results suggest involvement of serotoninergic antagonism in the THP-induced hypothermia in rats
腹腔注射dl-四氢巴马汀（THP；10 - 50毫克/千克）对室温下大鼠的结肠温度和下丘脑5-羟色胺（5-羟色胺，5-HT）释放均产生了成比例的降低。体温过低是由皮肤血管舒张和代谢降低引起的。在通过注射5,7-二羟基色胺导致脑5-HT耗竭的大鼠中，或在通过1-(2,5-二甲氧基-4-碘苯基)-2-氨基丙烷激活5-HT2A受体的大鼠中，或在通过(-)-吲哚洛尔产生5-HT1A受体拮抗剂的大鼠中，THP诱导的体温过低均显著减弱。结果表明，5-羟色胺能拮抗作用参与了THP诱导的大鼠体温过低。
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