Hooper P T
Acta Neuropathol. 1975;31(4):325-34. doi: 10.1007/BF00687927.
Spongy degeneration or status spongiosus of the central nervous system (CNS) was described in a number of domestic animal species, notably sheep, cattle, pigs and in one goat. The condition was characterized by diffuse or focal vacuolation, or polymicrocavitation of the CNS, particularly the white matter. The vacuolation showed a well defined pattern of distribution following a number of myelinated tracts in CNS white matter, in isolated fibres crossing grey matter in the brain stem, and along grey and white matter borders in the cerebrum and spinal cord. The vacuoles were not altered by a variety of methods of rapid brain fixation, processing and staining. The appearance of the vacuolation repeatedly favouring the same areas in the CNS in a large number of animals studied, its common origin either by hepatocerebral disease or hyperammonaemia, strongly suggests that CNS spongy degeneration of domestic animals is a distinct disease entity.
中枢神经系统（CNS）的海绵状变性或海绵状态在许多家畜物种中都有描述，特别是绵羊、牛、猪以及一只山羊。该病的特征是中枢神经系统出现弥漫性或局灶性空泡化，或多微腔形成，尤其是白质。空泡化在中枢神经系统白质中的一些有髓神经纤维束、脑干中穿过灰质的孤立纤维以及大脑和脊髓的灰质与白质边界处呈现出明确的分布模式。通过多种快速脑固定、处理和染色方法，空泡并未发生改变。在大量研究的动物中，空泡化反复出现在中枢神经系统的相同区域，其共同起源于肝脑疾病或高氨血症，这强烈表明家畜的中枢神经系统海绵状变性是一种独特的疾病实体。
