Yu J, Cui R, Tong S
Renal Department, Changhai Hospital, Second Military Medical College, Shanghai 200433, China.
Zhonghua Xue Ye Xue Za Zhi. 2001 Aug;22(8):415-7.
To investigate the clinicopathologic characteristics of renal chronic graft versus host disease (GVHD) after allogeneic peripheral blood hematopoietic transplantation(HSCT).
Clinical and pathological data from a patient with post-BMT GVHD were analysed with a related references review.
The patient developed nephrotic syndrome (NS) 8 months after allogeneic HSCT. Renal biopsy revealed irregular thickening of glomerular basement membrane with granular deposits of IgG along it. Electronic microscopy showed electron dense deposits with increased mesangial matrix and cells in subepithelial and mesangial area.
NS occurred after HSCT might be an autoimmune glomerulonephritis. Immune suppressor could reduce the incidence of NS in the HSCT patients. Cell-cept had a good efficacy in the treatment and renal biopsy played an important role in the diagnosis and prognosis of renal cGVHD.
探讨异基因外周血造血移植（HSCT）后肾慢性移植物抗宿主病（GVHD）的临床病理特征。
分析1例异基因造血干细胞移植后发生移植物抗宿主病患者的临床和病理资料，并复习相关文献。
该患者在异基因造血干细胞移植后8个月出现肾病综合征（NS）。肾活检显示肾小球基底膜不规则增厚，沿基底膜有IgG颗粒状沉积。电子显微镜显示电子致密沉积物，系膜基质增加，上皮下和系膜区细胞增多。
造血干细胞移植后发生的肾病综合征可能是自身免疫性肾小球肾炎。免疫抑制剂可降低造血干细胞移植患者肾病综合征的发生率。骁悉治疗效果良好，肾活检在慢性移植物抗宿主病肾病的诊断和预后中起重要作用。
