Galen R S, Reiffel J A, Gambino R
JAMA. 1975 Apr 14;232(2):145-7.
Total serum enzyme activity for creatine phosphokinase (CPK), alpha-hydroxybutyric dehydrogenase (HBDH), lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT), as well as the isoenzymes of CPK and LDH, were measured on admission and for ten subsequent days in 100 patients admitted consecutively to a coronary care unit. On discharge, patients were classified by a cardiologist as either having or not having suffered an acute myocardial infarction (MI) on the basis of clinical and electrocardiographic criteria--without knowledge of the enzyme studies. The combined use of CPK and LDH isoenzyme levels provided the greatest laboratory discrimination between the two clinical groups (MI vs non-MI). The routine use of HBDH and SGOT levels can be abandoned in the setting of a coronary care unit if CPK and LDH isoenzyme assays are available.
对连续收治入冠心病监护病房的100例患者，在入院时及随后十天测定其血清肌酸磷酸激酶（CPK）、α-羟丁酸脱氢酶（HBDH）、乳酸脱氢酶（LDH）和血清谷草转氨酶（SGOT）的总酶活性，以及CPK和LDH的同工酶。出院时，由心脏病专家根据临床和心电图标准对患者进行分类，判定是否发生急性心肌梗死（MI），而不了解酶学检查结果。CPK和LDH同工酶水平的联合应用在两个临床组（MI组与非MI组）之间提供了最大的实验室鉴别能力。如果有CPK和LDH同工酶检测，在冠心病监护病房环境下可不再常规使用HBDH和SGOT水平检测。
