Wassmer E, Carter P F, Quinn E, McLean N, Welsh G, Seri S, Whitehouse W P
Department of Neurology, Birmingham Children's Hospital, UK.
Dev Med Child Neurol. 2001 Nov;43(11):735-8. doi: 10.1017/s0012162201001347.
The study aimed to determine if melatonin could reliably induce sleep in children undergoing sleep EEG without affecting the usefulness of the EEG itself. One hundred and sixty three children (112 males, 51 females; mean age 8 years, range 1 to 16 years) referred for sleep EEG were studied. The children were given 2 to 10 mg of melatonin, depending on age, just before EEG recording. Measurements included sleep-onset latency, adverse effects, and acceptability of the EEG. Usefulness and acceptability of melatonin-induced sleep EEG were compared with the standard technique of sleep EEG following sleep deprivation in 30 children (matched for sex and age). Sleep was obtained in 79% of the 163 children who received melatonin after an average of 33 minutes. Yield of epileptiform abnormalities demonstrated in the melatonin sleep EEG was similar to that reported in the literature for sleep-deprived EEGs. There was no significant adverse effect. When compared, a melatonin-induced sleep EEG was as useful as a sleep-deprived EEG. However, the children's behaviour on the day of the melatonin-induced sleep EEG recording was more acceptable to parents.
该研究旨在确定褪黑素是否能在不影响睡眠脑电图本身效用的情况下，可靠地诱导接受睡眠脑电图检查的儿童入睡。对163名因睡眠脑电图检查前来就诊的儿童（112名男性，51名女性；平均年龄8岁，年龄范围1至16岁）进行了研究。在脑电图记录前，根据年龄给儿童服用2至10毫克褪黑素。测量指标包括入睡潜伏期、不良反应以及脑电图的可接受性。将褪黑素诱导睡眠脑电图的效用和可接受性与30名（年龄和性别匹配）睡眠剥夺后进行睡眠脑电图的标准技术进行了比较。在接受褪黑素治疗的163名儿童中，79%的儿童平均在33分钟后入睡。褪黑素睡眠脑电图中癫痫样异常的检出率与文献中报道的睡眠剥夺脑电图相似。没有明显的不良反应。相比之下，褪黑素诱导睡眠脑电图与睡眠剥夺脑电图一样有用。然而，在进行褪黑素诱导睡眠脑电图记录当天，儿童的行为更易为家长接受。
