Hamel M J, Odhacha A, Roberts J M, Deming M S
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, GA 30341-3724, USA.
Bull World Health Organ. 2001;79(11):1014-23.
To lay the basis for planning an improved malaria control programme in Bungoma District, Kenya.
By means of a cluster sample household survey an investigation was conducted into the home management of febrile children, the use of bednets, and attendance at antenatal clinics.
Female carers provided information on 314 recently febrile children under 5 years of age, of whom 43% received care at a health facility, 47% received an antimalarial drug at home, and 25% received neither. Of the antimalarial treatments given at home, 91% were started by the second day of fever and 92% were with chloroquine, the nationally recommended antimalarial at the time. The recommended dosage of chloroquine to be administered over three days was 25 mg/kg but the median chloroquine tablet or syrup dosage given over the first three days of treatment was 15 mg/kg. The total dosages ranged from 2.5 mg/kg to 82 mg/kg, administered over one to five days. The dosages were lower when syrup was administered than when tablets were used. Only 5% of children under 5 years of age slept under a bednet. No bednets had been treated with insecticide since purchase. At least two antenatal visits were made by 91% of pregnant women.
Carers are major and prompt providers of antimalarial treatment. Home treatment practices should be strengthened and endorsed when prompt treatment at a health facility is impossible. The administration of incorrect dosages, which proved common with chloroquine, may occur less frequently with sulfadoxine-pyrimethamine, as its dosage regimen is simpler. High levels of utilization of antenatal clinics afford the opportunity to achieve good coverage with presumptive intermittent malaria treatments during pregnancy, and to reach the goal of widespread bednet use by pregnant women and children by distributing nets during antenatal clinic visits.
为肯尼亚邦戈马区规划改进的疟疾控制项目奠定基础。
通过整群抽样家庭调查,对发热儿童的家庭管理、蚊帐使用情况以及产前诊所就诊情况进行了调查。
女性照料者提供了314名5岁以下近期发热儿童的信息,其中43%在医疗机构接受治疗,47%在家中接受抗疟药物治疗,25%两者均未接受。在家中进行的抗疟治疗中,91%在发热第二天开始,92%使用氯喹,这是当时国家推荐的抗疟药物。推荐的氯喹三日给药剂量为25mg/kg,但治疗头三天给予的氯喹片剂或糖浆的中位剂量为15mg/kg。总剂量范围为2.5mg/kg至82mg/kg,给药时间为1至5天。服用糖浆时的剂量低于使用片剂时的剂量。5岁以下儿童中只有5%睡在蚊帐下。自购买以来,没有蚊帐用杀虫剂处理过。91%的孕妇至少进行了两次产前检查。
照料者是抗疟治疗的主要且及时的提供者。当无法在医疗机构及时治疗时,应加强并认可家庭治疗方法。氯喹常见的给药剂量错误,在使用周效磺胺 - 乙胺嘧啶时可能较少发生,因为其给药方案更简单。产前诊所的高利用率为在孕期实现推定间歇性疟疾治疗的良好覆盖率提供了机会,并通过在产前诊所就诊时分发蚊帐来实现孕妇和儿童广泛使用蚊帐的目标。