Pfeffer S R
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
J Cell Biol. 2001 Dec 10;155(6):873-5. doi: 10.1083/jcb.200109095.
In this issue, Short et al. report the discovery of a protein named Golgin-45 that is located on the surface of the middle (or medial) cisternae of the Golgi complex. Depletion of this protein disrupts the Golgi complex and leads to the return of a resident, lumenal, medial Golgi enzyme to the endoplasmic reticulum. These findings suggest that Golgin-45 serves as a linchpin for the maintenance of Golgi complex structure, and offer hints as to the mechanisms by which the polarized Golgi complex is constructed.
在本期杂志中，肖特等人报告发现了一种名为高尔基体蛋白45的蛋白质，它位于高尔基体复合体中间（或内侧）潴泡的表面。这种蛋白质的缺失会破坏高尔基体复合体，并导致一种驻留的、腔内的、内侧高尔基体酶返回内质网。这些发现表明，高尔基体蛋白45是维持高尔基体复合体结构的关键因素，并为极化高尔基体复合体的构建机制提供了线索。
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