Meschia J F, Brown R D, Brott T G, Hardy J, Atkinson E J, O'Brien P C
Department of Neurology, Section of Pharmacology, Mayo Clinic, Jacksonville, Fla, USA.
Stroke. 2001 Dec 1;32(12):2939-41. doi: 10.1161/hs1201.099795.
We sought to determine pedigree availability for a concordant sibling pair study of genetic risk factors in ischemic stroke.
Probands with confirmed ischemic stroke were prospectively enrolled. Family histories were obtained by systematic interview. A study neurologist prospectively assigned stroke subtype.
Of 310 probands (median age, 75 years; range, 26 to 97 years; 48% women), 75% had at least 1 living sibling; 10%, at least 1 concordant living sibling; 2%, at least 1 concordant sibling living in the same city; and 7%, at least 1 concordant living and 1 discordant living sibling. Likelihood of having a concordant sibling increased significantly with proband age, even after adjustment for sibship size (P=0.002). Positive family history of stroke was not related to either proband stroke subtype or risk factor profile.
Approximately 10 probands were screened to find 1 potentially concordant living sibling. A concordant sibling pair study should be multicentered and enable enrollment of siblings from diverse geographic areas.
我们试图确定在缺血性卒中遗传风险因素的一致性同胞对研究中家系的可获得性。
前瞻性纳入确诊为缺血性卒中的先证者。通过系统访谈获取家族史。一名研究神经科医生前瞻性地确定卒中亚型。
在310名先证者中（中位年龄75岁；范围26至97岁；48%为女性），75%至少有1名在世同胞；10%至少有1名一致性在世同胞；2%至少有1名一致性同胞居住在同一城市；7%至少有1名一致性在世同胞和1名不一致性在世同胞。即使在校正同胞数量后，拥有一致性同胞的可能性也随先证者年龄显著增加（P = 0.002）。卒中的阳性家族史与先证者的卒中亚型或风险因素概况均无关。
大约筛查10名先证者才能找到1名潜在的一致性在世同胞。一致性同胞对研究应多中心开展，并能够纳入来自不同地理区域的同胞。
