DNA-Pt复合物的X射线光电子能谱。DNA与顺二氯二氨铂（II）形成O6（鸟嘌呤）-N7（鸟嘌呤）螯合的证据。
X-ray photoelectron spectroscopy of DNA-Pt complexes. Evidence of O6 (Gua)-N7 (Gua) chelation of DNA with cis- dichlorodiamine platinum(II).
作者信息
Millard M M, Macquet J P, Theophanides T
出版信息
Biochim Biophys Acta. 1975 Aug 21;402(2):166-70. doi: 10.1016/0005-2787(75)90035-0.
PMID:1174534
Abstract
The binding energies of nitrogen, oxygen, phosphorus, chlorine and Pt in several DNA - Pt (II) complexes are reported and discussed. The nitrogen band of DNA is slightly shifted upon complexation with Pt. Oxygen binding energies in the complexes studied clearly show that cis-Pt(NH3)2Cl2 forms a specific chelate N7(Gua) - O6 (Gua) with DNA as opposed to trans-Pt(NH3)2Cl2 and the other Pt compounds which react only with the N7(Gua) site of DNA.
摘要
报道并讨论了几种DNA - Pt（II）配合物中氮、氧、磷、氯和铂的结合能。DNA的氮带在与铂络合时略有移动。所研究配合物中的氧结合能清楚地表明，顺式Pt(NH3)2Cl2与DNA形成特定的螯合物N7（鸟嘌呤）- O6（鸟嘌呤），这与反式Pt(NH3)2Cl2及其他仅与DNA的N7（鸟嘌呤）位点反应的铂化合物不同。
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