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Reactivity of aorta and portal vein in germfree rats.

作者信息

Altura B T, Altura B M, Baez S

出版信息

Blood Vessels. 1975;12(4):206-18. doi: 10.1159/000158057.

Abstract

The responsiveness of conventional and germfree rat aortas and portal veins to vasoactive agents were compared in vitro. The results indicate: (1) aortas and portal veins from germfree rats exhibit an attenuated reactivity to angiotensin, vasopressin and epinephrine but not to KC1; (2) the dose-response curves for epinephrine and the peptides were shifted to the right concomitant with a decrease in maximum contractile tension, and (3) CaC12 dose-response curves obtained on potassium-depolarized aorta were not different from one another, whereas those obtained on portal veins from germfree animals were shifted to the right with a concomitant decrease in maximum response. In addition, aortas and portal veins from germfree rats were found to exhibit a higher total Ca content (but not Mg or water) when compared to conventional animals.

摘要

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