帕米膦酸盐治疗反射性交感神经营养不良：29例
Treatment of reflex sympathetic dystrophy with pamidronate: 29 cases.
作者信息
Kubalek I, Fain O, Paries J, Kettaneh A, Thomas M
机构信息
Service de Médecine Interne, Hôpital Jean Verdier, Assistance Publique-Hôpitaux de Paris, Université Paris Nord, UPRES Recherche Clinique et Thérapeutique, Avenue du 14 Juillet, 93140 Bondy, France.
出版信息
Rheumatology (Oxford). 2001 Dec;40(12):1394-7. doi: 10.1093/rheumatology/40.12.1394.
OBJECTIVE
To evaluate the efficacy of treatment with pamidronate in reflex sympathetic dystrophy (RSD) refractory to previous treatment.
METHODS
We studied the response (disappearance of pain and functional improvement) to pamidronate (60 mg/day for 3 days) in 29 patients with RSD refractory to previous treatment for at least 14 days.
RESULTS
On day 45, complete pain disappearance was observed in 86.2% of patients and functional improvement in 70%. The mean delay until the pain disappeared was 20+/-14 days and the delay until functional improvement was observed was 29+/-18 days. The mean delay of functional improvement was shorter in patients with post-traumatic RSD. Multivariate analysis did not reveal any factor predictive of response to treatment. Six (20.7%) patients suffered from side-effects (fever, diarrhoea).
CONCLUSION
Pamidronate appeared to be effective in the treatment of refractory RSD; however, these results need to be confirmed by a controlled placebo study.
目的
评估帕米膦酸治疗既往治疗无效的反射性交感神经营养不良（RSD）的疗效。
方法
我们研究了29例既往治疗至少14天无效的RSD患者对帕米膦酸（60mg/天，共3天）的反应（疼痛消失和功能改善）。
结果
在第45天，86.2%的患者疼痛完全消失，70%的患者功能得到改善。疼痛消失的平均延迟时间为20±14天，功能改善的观察延迟时间为29±18天。创伤后RSD患者功能改善的平均延迟时间较短。多变量分析未发现任何预测治疗反应的因素。6例（20.7%）患者出现副作用（发热、腹泻）。
结论
帕米膦酸似乎对难治性RSD有效；然而，这些结果需要通过对照安慰剂研究来证实。
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