肾脏中多巴胺受体在血压调节中的作用。

Role of dopamine receptors in the kidney in the regulation of blood pressure.

作者信息

Jose Pedro A, Eisner Gilbert M, Felder Robin A

机构信息

Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA.

出版信息

Curr Opin Nephrol Hypertens. 2002 Jan;11(1):87-92. doi: 10.1097/00041552-200201000-00013.

DOI:10.1097/00041552-200201000-00013

PMID:11753092

Abstract

Regulation by dopamine of cardiovascular function, renal function and systemic blood pressure regulation is multifaceted. Each of the five dopamine receptor subtypes participates in the regulation of blood pressure by mechanisms specific for the subtype. Some receptors regulate blood pressure by influencing the central or peripheral nervous system; others influence epithelial transport and regulate the secretion and receptors of several humoral agents. The D1, D3, and D4 receptors interact with the renin-angiotensin system, while the D2 and D5 receptors interact with the sympathetic nervous system to regulate blood pressure.

摘要

多巴胺对心血管功能、肾功能及全身血压调节的作用是多方面的。五种多巴胺受体亚型中的每一种都通过特定于该亚型的机制参与血压调节。一些受体通过影响中枢或外周神经系统来调节血压；另一些则影响上皮转运并调节几种体液因子的分泌和受体。D1、D3和D4受体与肾素-血管紧张素系统相互作用，而D2和D5受体与交感神经系统相互作用以调节血压。